Given the challenges and global uncertainties in the business’s, the use of futurism to improve management in space research center in Iran has become very important. Hence, space sector needs continuous futurology improvement in its systems and processes to obtain higher levels of reliability. Therefore, this study is aiming to design a model to create an organization with high reliability. So, this research is among developing research. In terms of the nature and approach of research, it is a causal-effect research, while it should also be noted that the present study is mixed by Grounded theory. This research has done based on qualitative part of the research and semi-structured interviews with 20 experts and knowledgeable experts in Iran Space Research Institute and active academic experts at universities. Firstly, categories and subcategories have been selected through individual interviews with experts in the field of reliability based on snowball sampling method. The statistical population of this research in a small part consists of active employees of the organization in the Iranian Space Research Institute of 1000 people. The statistical sample in this research is 277 people and the sampling method is also available. The results showed that, security activities, learning and experience survival, high interaction ability activities, job rotation and trust, high learning ability and difficulties at work activities, managers' special attention to supply line forces, high transfer rate, knowledge management, teamwork, loyalty and dignity, teamwork and collaboration, organizational knowledge management, commitment to flexibility, talent management and organized turmoil are essential to create a highly reliable organization.